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Klinik & Team

Univ. Prof. Dr. med. Marcos Tatagiba

Funktion: Ärztlicher Direktor
Tel: +49 7071 29 80325
Fax: +49 7071 29 52 45

Überblick über die Forschungsinteressen


Schwannomas and neurofibromas, also kwown as peripheral nerve sheath tumors (PNST) are benign tumors that arise from the nerve sheath of peripheral nerves. PNST are commonly solitary tumors, but they may occur in multiple areas of the body in Neurofibromatosis. Basic research includes genotype characterization of different phenotypes of the diseases. A novel third type of recurrent NF1 microdeletion was shown to be mediated by nonallelic homologous recombination between low-copy repeats in chromosome 17q.

Benign brain tumors such as the low grade gliomas may have different clinical evolution and prognosis. Molecular markers have been newly described with the support of the data base of the national glioma network program. Basic research on malignant brain tumors such as the glioblastomas, analyses the role of extracelular matrix and aquaporine on peritumoral edema formation. In addition, we have conducted in vitro and in vivo studies on hyperecin as intraoperative tumor visualization and photodynamic therapy tool.

To support the research in this rapidly developing field we created a new section of Neurooncology together with the Department of Neurology with an own "W3 Professorship".


With introduction of a new intraoperative high field mri (iMRI) studies are conducted to analyse intraoperative visualization of residual tumor: the role of perfusion-weighted imaging in a high-field intraoperative MR scanner. We currently study the results of high grade glioma surgery in a high-field iMRI – in regard to improvement of the extent of resection. Preoperative and intraoperative multimodal brain mappings are achieved with association of tool such as functional mri studies, transcranial magnetic stimulation (TMS) and intraoperative electrophysiology.

The role of the cerebellum on biological motion processing was studied with fMRI examinations. It was shown that cerebellum plays an important role in cognitive processes and motion processing, and that it communicates with right superior temporal gyrus.


The auditory (cochlear) nerve has no capability to spontaneously recover after injury. One of the reasons it just the fact that it contains central nervous system tissue and myelination is given by oligodendrocytes. The cochlear nerve differs tremendously from other cranial nerves, i.e. the facial nerve, which contains peripheral nerve myelin from Schwann cells. Regeneration of injured cochlear nerve of the adult rats was analysed following intrathecal application of antibodies against myelin-associated nerve growth inhibitor. Both morphological and electrophysiologial (auditory evoked potentials) investigations have shown some degree of regeneration, which have never been demonstrated.


The neuroprosthetics group of the Department of Neurosurgery implements invasive interfaces with the human brain in diseased conditions to modulate pathological network activity and to decode ongoing oscillatory behaviour for communication and therapeutic purposes. In parallel to these approaches this group conducts electrophysiological and neuroimaging studies to implement adaptive neuromodulation based on a physiological understanding of cortical networks. To support research in this rapidly developing field a new Section on Translational Neurosurgery with an own “W3” professorship was created in the Department of Neurosurgery.

Vita & Qualifikationen

Personal Information

Birthday: March 9, 1963 in Victoria, E.S., Brazil

Citzisenschip: German

Medical Study

University of the State of Rio de Janeiro, Rio de Janeiro, Brazil, from 1980 to 1986. Residency Program in Neurosurgery. Neurosurgical Training from 1987 to 1993 at the Department of Neurosurgery, Nordstadt Hospital, Hannover, Germany, under the Chairmanship of Prof. Dr. Dr. Madjid Samii. Board of Neurosurgery in March, 1993 (European Certificate)

Doctorial Thesis

Accomplished in January 1992 at Hannover Medical School, Hannover, Germany “Significance for postoperative hearing of preserving the labyrinth in vestibular schwannoma surgery”

Post Doctorial Thesis

Accomplished in February 1998 at Hannover Medical School, Hannover, Germany “Regeneration of axotomized acoustic nerve of adult rat after intrathecal treatment with the IN-1 antibody against neurite growth inhibitors”.

Major University Positions

  • 2000 Vice Director, International Neuroscience Institute, Hannover
  • 2002 Vice Director, Dept. of Neurosurgery, University of Freiburg
  • 2003 Director and Chairman, Dept. of Neurosurgery, University of Tübingen
  • 2006 Appointed as Chairman and Director, Dept. of Neurosurgery, University of Zurich

Scientific Publications (As Of 2012)

  • Journals: 300 peer-reviewed articles
  • Book Chapters: 25 chapters
  • Books (Autor/Editor): 6 books

Areas of special interests

  • Basic Research: Neurooncology, including Neurofibromatosis, Neuroregeneration of the Peripheral and the Central Nervous System
  • Clinical Research: Skull Base Tumors, including CP Angle tumors

Mastership of scientific and medial societies

  • Member of the German Society of Neurosurgery (Deutsche Gesellschaft für Neurochirurgie)
  • Member of the Congress of Neurological Surgeons (CNS-USA)
  • Member of the American Association of Neurological Surgeons (AANS-USA)
  • Member of the German Society of Skull Base (Deutsche Gesellschaft für Schädelbasischirurgie)
  • Member of the Executive Committee of the German Skull Base Society as Treasurer
  • Member of the European Skull Base Society
  • Member of the Brazilian Society of Neurosurgery (Sociedade Brasileira de Neurocirurgia)
  • Member of the German Academy of Neurosurgery (GANS)
  • Member of the Academia Eurasiana
  • President of the German Academy of Neurosurgery (2010-2012)
  • President-elect German-speaking Society of Skull Base (Gesellschaft für Schädelbasischirurgie)

Major Prizes and honors

  • 1997 Young Neurosurgeon Award. World Federation of Neurosurgical Societies.
  • 2001 Aesculap/EANS Prize. European Association of Neurosurgical Societies2001 Academic Adviser of Jiangyin International Cooperative Neuro-Center, Southeast University School of Medicine, China
  • 2002 Prize of the Neurosurgical Research Foundation Prize. German Society of Neurosurgery
  • 2003 Visiting Professor at Wayne State University, School of Medicine, Department of Neurological Surgery and Children’s Hospital of Michigan, Detroit, MI (USA)
  • 2007 Innovationspreis Medizintechnik – Federal Ministry of Educationa and Science (BMBF), Germany
  • 2008 Visiting Professor, University of the State of Rio de Janeiro, Brazil
  • 2010 Visiting Professor, People’s Hospital, Affiliated Hospital of the University of Peking, Peoples Republic of China
  • 2013 Comenda Estrela Spica da Educacao e Cultura, Capitulo Norte da Academia Brasileira de Neurocirurgia
  • 2014 Honorary Member, Brazilian Academy of Military Medicine
  • 2016 Keller Lecturer 2016. Department of Neurosurgery, University of Cincinnati, OH, USA