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Univ. Prof. Dr. med. Marcos Tatagiba

Funktion: Ärztlicher Direktor

Telefon: +49 7071 29 80325 (Sekretariat)
Fax: +49 7071 29 52 45

E-Mail

 

Overview of Research Interests

Neurooncology:

Schwannomas and neurofibromas, also known as peripheral nerve sheath tumors (PNST), are benign tumors that arise from the nerve sheath of peripheral nerves. PNST are commonly solitary tumors, but they may occur in multiple areas of the body in Neurofibromatosis. Basic research includes genotype characterization of different disease phenotypes. A novel third type of recurrent NF1 microdeletion was shown to be mediated by nonallelic homologous recombination between low-copy repeats in chromosome 17q.
Benign brain tumors such as low grade gliomas may have different clinical evolution and prognosis. Molecular markers have been newly described with the support of the data base of the national glioma network program. Basic research on malignant brain tumors such as glioblastomas analyses the role of extracellular matrix and aquaporine on peritumoral edema formation. In addition, we have conducted in vitro and in vivo studies on hyperecin as intraoperative tumor visualization and a photodynamic therapy tool.

Neuroimaging
With introduction of a new intraoperative high field MRI (iMRI), studies are conducted to analyse intraoperative visualization of residual tumor: the role of perfusion-weighted imaging in a high-field intraoperative MR scanner. We are currently studying the results of high grade glioma surgery in a high-field iMRI – in terms of improvement of the extent of resection. Preoperative and intraoperative multimodal brain mappings are achieved by associating tools such as functional MRI studies, transcranial magnetic stimulation (TMS) and intraoperative electrophysiology.

The role of the cerebellum on biological motion processing was studied with fMRI examinations. It was shown that the cerebellum plays an important role in cognitive processes and motion processing, and that it communicates with right superior temporal gyrus.

Neuroregeneration

The auditory (cochlear) nerve has no capability to spontaneously recover after injury. One of the reasons for this is just the fact that it contains central nervous system tissue and myelination is given by oligodendrocytes. The cochlear nerve differs tremendously from other cranial nerves, i.e. the facial nerve, which contain peripheral nerve myelin from Schwann cells. Regeneration of injured cochlear nerve in adult rats was analyzed following intrathecal application of antibodies against myelin-associated nerve growth inhibitor. Both morphological and electrophysiologial (auditory evoked potentials) investigations have shown some degree of regeneration, something which had never before been demonstrated.

Neuroprosthetics

The neuroprosthetics group of the Department of Neurosurgery implements invasive interfaces with human brains that are in diseased conditions in order to modulate pathological network activity and to decode ongoing oscillatory behavior for communication and therapeutic purposes. In parallel to these approaches this group conducts electrophysiological and neuroimaging studies to implement adaptive neuromodulation based on a physiological understanding of cortical networks. To support research in this rapidly developing field, a new Section on Translational Neurosurgery with its own “W3” professorship was created in the Department of Neurosurgery.

Selected Publications

1. Sokolov AA, Erb M, Gharabaghi A, Grodd W, Tatagiba M, Pavlova MA. Biological motion processing: the left cerebellum communicates with the right superior temporal sulcus. Neuroimage. 2012 Feb 1;59(3):2824-30.

2. Hartmann C, Hentschel B, Tatagiba M, Schramm J, Schnell O, Seidel C, Stein R, Reifenberger G, Pietsch T, von Deimling A, Loeffler M, Weller M; German Glioma Network. Molecular markers in low-grade gliomas: predictive or prognostic? Clin Cancer Res. 2011 Jul 1;17(13):4588-99.

3. Bengesser K, Cooper DN, Steinmann K, Kluwe L, Chuzhanova NA, Wimmer K, Tatagiba M, Tinschert S, Mautner VF, Kehrer-Sawatzki H. A novel third type of recurrent NF1 microdeletion mediated by nonallelic homologous recombination between LRRC37B-containing low-copy repeats in 17q11.2. Hum Mutat. 2010 Jun;31(6):742-51.

4. Feigl GC, Ritz R, Moraes M, Klein J, Ramina K, Gharabaghi A, Krischek B, Danz S, Bornemann A, Liebsch M, Tatagiba M. Resection of malignant brain tumors in eloquent cortical areas: a new multimodal approach combining 5-aminolevulinic acid and intraoperative monitoring. J Neurosurg. 2010 Aug;113(2):352-7.

5. Sokolov AA, Gharabaghi A, Tatagiba M, Pavlova M. Cerebellar engagement in an action observation network. Cereb Cortex. 2010 Feb;20(2):486-91.

 

Curriculum vitae

Birthday: March 9, 1963 in Victoria, E.S., Brazil
Citzisenschip: German
Position: Professor of Neurosurgery, Chairman and Director
Office Address:
Department of Neurosurgery
Eberhard-Karls Universty of Tuebingen
Hoppe-Seyler-Str. 3
D-72076 Tuebingen
Germany
Office Tel.: +49 7071 29 8 0325
Office Fax: +49 7071 29 4549
Email: marcos.tatagiba@med.uni-tuebingen.de

Medical Study

University of the State of Rio de Janeiro, Rio de Janeiro, Brazil, from 1980 to 1986

Residency Program in Neurosurgery
Neurosurgical Training from 1987 to 1993 at the Department of Neurosurgery, Nordstadt Hospital, Hannover, Germany, under the Chairmanship of Prof. Dr. Dr. Madjid Samii.
Board of Neurosurgery in March, 1993 (European Certificate)

Doctoral Thesis

Accomplished in January 1992 at Hannover Medical School, Hannover, Germany
“Significance for postoperative hearing of preserving the labyrinth in vestibular schwannoma surgery”

Post-doctoral Thesis

Accomplished in February 1998 at Hannover Medical School, Hannover, Germany
“Regeneration of axotomized acoustic nerve of adult rat after intrathecal treatment with the IN-1 antibody against neurite growth inhibitors”.

Major University Positions

2000 Vice Director, International Neuroscience Institute, Hannover
2002 Vice Director, Dept. of Neurosurgery, University of Freiburg
2003 Director and Chairman, Dept. of Neurosurgery, University of Tübingen
2006 Appointed as Chairman and Director, Dept. of Neurosurgery, University of Zurich

Scientific Publications (as of 2012):

Journals: 237 peer-reviewed articles
Book Chapters: 25 chapters
Books (Autor/Editor): 4 books

Areas of Special Interest:

Basic Research: Neurooncology, including Neurofibromatosis
Neuroregeneration of the Peripheral and the Central Nervous System
Clinical Research: Skull Base Tumors, including CP Angle tumors

Membership of Scientific and Medical Societies

Member of the German Society of Neurosurgery (Deutsche Gesellschaft für Neurochirurgie)
Member of the Congress of Neurological Surgeons (CNS-USA)
Member of the American Association of Neurological Surgeons (AANS-USA)
Member of the German Society of Skull Base (Deutsche Gesellschaft für Schädelbasischirurgie)
Member of the Executive Committee of the German Skull Base Society as Treasurer
Member of the European Skull Base Society
Member of the Brazilian Society of Neurosurgery (Sociedade Brasileira de Neurocirurgia)
Member of the German Academy of Neurosurgery (GANS)
Member of the Academia Eurasiana
President of the German Academy of Neurosurgery (2010-2011)
President-elect German-speaking Society of Skull Base (Gesellschaft für Schädelbasischirurgie)

Major Prizes

1997 Young Neurosurgeon Award. World Federation of Neurosurgical Societies.
2001 Aesculap/EANS Prize. European Association of Neurosurgical Societies
2002 Neurosurgical Research Foundation Prize. German Society of Neurosurgery
2007 Innovation Preis “Medizintechnik” – Federal Ministry of Science (BMBF)

 
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